Warning: Declaration of action_plugin_denyactions::register(Doku_Event_Handler &$controller) should be compatible with DokuWiki_Action_Plugin::register(Doku_Event_Handler $controller) in /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/denyactions/action.php on line 40

Warning: Declaration of action_plugin_tagfilter::register(&$controller) should be compatible with DokuWiki_Action_Plugin::register(Doku_Event_Handler $controller) in /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/tagfilter/action.php on line 60

Warning: Cannot modify header information - headers already sent by (output started at /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/denyactions/action.php:40) in /homepages/7/d191477725/htdocs/e-cigarette-research/inc/auth.php on line 430

Warning: Use of undefined constant wrap - assumed 'wrap' (this will throw an Error in a future version of PHP) in /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/ckgedit/action/meta.php on line 649

Warning: Cannot modify header information - headers already sent by (output started at /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/denyactions/action.php:40) in /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/ckgedit/action/meta.php on line 669

Warning: Cannot modify header information - headers already sent by (output started at /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/denyactions/action.php:40) in /homepages/7/d191477725/htdocs/e-cigarette-research/inc/actions.php on line 38

Warning: Cannot modify header information - headers already sent by (output started at /homepages/7/d191477725/htdocs/e-cigarette-research/lib/plugins/denyactions/action.php:40) in /homepages/7/d191477725/htdocs/e-cigarette-research/lib/tpl/dokuwiki/main.php on line 12
A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects [E-Cigarette Research]
research:documents:85x628us

A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects

Journal Article 1)

Background:
Electronic “cigarettes” are marketed to tobacco users as potential reduced exposure products (PREP), albeit with little information regarding electronic cigarette user toxicant exposure and effects. This information may be obtained by adapting clinical laboratory methods used to evaluate other PREPs for smokers.

Methods:
Thirty-two smokers participated in four independent Latin-square ordered conditions that differed by product: own brand cigarette, “NPRO” electronic cigarettes (NPRO EC; 18 mg cartridge), “Hydro” electronic cigarettes (Hydro EC; 16 mg cartridge), or sham (unlit cigarette). Participants took 10 puffs at two separate times during each session. Plasma nicotine and carbon monoxide (CO) concentration, heart rate, and subjective effects were assessed.

Results:
Own brand significantly increased plasma nicotine and CO concentration and heart rate within the first five minutes of administration whereas NPRO EC, Hydro EC, and sham smoking did not. Own brand, NPRO EC, and Hydro EC (but not sham) significantly decreased tobacco abstinence symptom ratings and increased product acceptability ratings. The magnitude of symptom suppression and increased acceptability was greater for own brand than for NPRO EC and Hydro EC.

Conclusions:
Under these acute testing conditions, neither of the electronic cigarettes exposed users to measurable levels of nicotine or CO, although both suppressed nicotine/tobacco abstinence symptom ratings.

Impact:
This study illustrates how clinical laboratory methods can be used to understand the acute effects of these and other PREPs for tobacco users. The results and methods reported here will likely be relevant to the evaluation and empirically based regulation of electronic cigarettes and similar products. Cancer Epidemiol Biomarkers Prev; 19(8); 1945–53. ©2010 AACR.


z-ref: 85x628us

1)
Eissenberg , et al. (2010), A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects, http://cebp.aacrjournals.org/content/19/8/1945 accessed: 2014-01-29
research/documents/85x628us.txt · Last modified: 2014/03/31 00:51 by rainman