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Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography–tandem mass spectrometry [E-Cigarette Research]
research:documents:wjnw8k5c
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Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography–tandem mass spectrometry

Journal Article 1)

Highlights

  • The new analysis method of TSNAs in replacement liquids by LC–MS/MS.
  • First article for the identification and quantification of TSNAs in replacement liquids.
  • The TSNA analytical data in 105 replacement liquids of E-cigarettes.

Abstract

A liquid chromatography–tandem mass spectrometric method was described to detect tobacco-specific nitrosamines (TSNAs) in replacement liquids of electronic cigarettes. Solid-phase extraction (SPE) and liquid–liquid extraction (LLE) were compared to each other to select the optimum clean-up method. Under the established condition, the limits of quantification of N′-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N′-nitrosoanabasine (NAB), and N′-nitrosoanatabine (NAT) were 0.06, 0.07, 0.06, and 0.04 μg/L respectively, by using 0.5 mL of replacement liquids, respectively, and the relative standard deviation was less than 10% at concentrations of 5.0 and 25.0 μg/L. The concentrations of TSNAs were measured in concentration ranges of 0.34–60.08 μg/L (64.8% detection frequency) for NNN, 0.22–9.84 μg/L (88.6% detection frequency) for NNK, 0.11–11.11 μg/L (54.3% detection frequency) for NNB, and 0.09–62.19 μg/L (75.2% detection frequency) for NAT in 105 replacement liquid brands from 11 electronic cigarette companies purchased in the Korean market.


z-ref: wjnw8k5c

1)
Kim & Shin (2013), Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography–tandem mass spectrometry, http://www.sciencedirect.com/science/article/pii/S0021967313005001#fig0010 accessed: 2013-08-09
research/documents/wjnw8k5c.txt · Last modified: 2014/03/28 16:46 by rainman