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A fresh look at tobacco harm reduction: the case for the electronic cigarette Journal Article Abstract Smokers of any age can reap substantial health benefits by quitting. In fact, no other single public health effort is likely to achieve a benefit comparable to large-scale smoking cessation. Surveys document that most smokers would like to quit, and many have made repeated efforts to do so. However, conventional smoking cessation approaches require nicotine addicted smokers to abstain fro…
ASH Fact Sheet 891- Use of e-cigarettes in Great Britain among adults and young people (2013) Document ASH has commissioned surveys on e-cigarette use starting in 2010 with a survey of smokers, followed in February 2012 and 2013 by surveys of all adults and in March 2013 with a survey of children aged 11 to 18.
ASSESSMENT OF THIRDHAND EXPOSURE TO NICOTINE FROM ELECTRONIC CIGARETTES Conference Paper Purpose: Electronic cigarettes (e-cigarettes) are new battery-powered devices that resemble tobacco cigarettes and convert nicotine solutions into inhalable vapors.
CASAA 2010 E-cigarette User Survey Results Web Page A Survey of over 200 users. ---------- answered question 2,217 skipped question What is your age group? Under 18 18 - 21 22 - 25 26 - 29 30 - 39 40 - 49 50 - 59
Chapter 12 - Cognitive, affective and motivational effects of smoking Book Section Publisher Summary This chapter discusses cognitive, affective, and motivational effects of smoking. The individual differences at genetic, personality, affective, and cognitive levels relate to the development of dependence and influence the effects of pharmacological and psychological interventions. It is found that smokers obtain benefits from nicotine, relative to their functioning when acutely abstinent,…
Does ANYONE have a valid definition of “addiction”? | Anti-THR Lies and related topics Blog Post Does ANYONE have a valid definition of “addiction”? Posted on 7 October 2013 by Carl V Phillips | 28 Comments by Carl V Phillips Sorry for the radio silence. Was traveling, and then exhausted and sick. During my travels, I had a few interesting debates about the concept of addiction, and promised to write the following, which I finally have completed. The funny thing about all debates about…
Electronic cigarette: a possible substitute for cigarette dependence Journal Article ABSTRACT: Cigarette smoking is the leading cause of premature mortality in western countries and it is important for smokers to stop as early as possible. Electronic cigarettes are a popular phenomenon of global proportion. Recent uncontrolled studies, reported that a certain number of smokers have quit using electronic cigarettes. This could hint a role for electronic cigarettes to be used for smoking ce…
Evaluating Nicotine Levels Selection and Patterns of Electronic Cigarette Use in a Group of "Vapers" Who Had Achieved Complete Substitution of Smoking Journal Article Background: Electronic cigarettes (ECs) are alternative-to-smoking nicotine delivery devices; consumers (commonly called vapers) use them in order to reduce or completely substitute smoking. The European Commission has released a proposal for a new Tobacco Product Directive that might reduce availability of nicotine-containin…
IDENTIFICATION OF CYTOTOXIC CHEMICALS IN THIRDHAND SMOKE Conference Paper (See note attachment for extended abstract) IDENTIFICATION OF CYTOTOXIC CHEMICALS IN THIRDHAND SMOKE Vasundhra Bahl*1,2, Suzaynn Schick 3, Mohamad Sleiman4, and Prue Talbot
Impact of an Electronic Cigarette on Smoking Reduction and Cessation in Schizophrenic Smokers: A Prospective 12-Month Pilot Study Journal Article Abstract: Background: Cigarette smoking is a tough addiction to break. This dependence is the most common dual diagnosis for individuals with schizophrenia. Currently three effective drugs are approved for smoking cessation: nicotine replacement therapy (NRT), varenicline and bupropion. However, some serious side effects of varenicline have been…
Intravenous Nicotine and Caffeine: Subjective and Physiological Effects in Cocaine Abusers Journal Article The subjective and physiological effects of intravenously administered caffeine and nicotine were compared in nine subjects with histories of using caffeine, tobacco, and cocaine.
Investigating the impact of nicotine on executive functions using a novel virtual reality assessment Journal Article Aims Nicotine is known to enhance aspects of cognitive functioning in abstinent smokers, but the effects on specific areas of executive functions and in non-smokers are inconclusive. This may be due in part to the poor sensitivity of tests used to assess executive functions. This study used a new virtual reality assessment of executive functions known as JEF (the Jansari asse…
Metabolism and Disposition Kinetics of Nicotine Journal Article Abstract Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a useful probe drug for phenotyping cytochrome P450 2A6 (CYP2A6). We review current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential thera…
Monoamine Oxidase Inhibition Dramatically Increases the Motivation to Self-Administer Nicotine in Rats Journal Article Nicotine is the major neuroactive compound of tobacco, which has, by itself, weak reinforcing properties. It is known that levels of the enzymes monoamine oxidase A (MAO-A) and MAO-B are reduced in the platelets and brains of smokers and that substances, other than nicotine, present in tobacco smoke have MAO-inhibitory activities.
Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices Journal Article A wide range of electronic cigarette (EC) devices, from small cigarette-like (first-generation) to new-generation high-capacity batteries with electronic circuits that provide high energy to a refillable atomizer, are available for smokers to substitute smoking.
Nicotine Addiction Journal Article This review gives an account of the cigarette as a highly efficient nicotine delivery system. It explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction to tobacco smoking. The basis of nicotine addiction rests on its effects on the brain, but addiction is also influenced by learned or conditioned factors, genetics, and social and environmental conditions.
Nicotine addiction and withdrawal Web Document . . . . Causes, incidence, and risk factors Tobacco is a plant grown for its leaves, which are smoked, chewed, or sniffed for a variety of effects. It is considered an addictive substance because it contains the chemical nicotine.
Nicotine and Health Blog Post This year, how about making a truly meaningful, life-altering New Year’s resolution? If you’re one of 44 million American smokers, we have one for you: Try separating the smoke from your nicotine fix. Doing so will save your life.
Nicotine: Medication or Scourge? Book Section The majority of people in most cultures uses psychoactive drugs. In our society only three such substances are legal and freely available: caffeine, alcohol, and nicotine. One of these, nicotine, is an endangered species as the laws against its use multiply in the United States.
Patterns of change in withdrawal symptoms, desire to smoke, reward motivation and response inhibition across 3 months of smoking abstinence Journal Article Aims We have demonstrated previously that acute smoking abstinence is associated with lowered reward motivation and impaired response inhibition. This prospective study explores whether these impairments, along with withdrawal-related symptoms, recover over 3 months of sustained abstinence.
Psychosocial Withdrawal Characteristics of Nicotine Compared with Alcohol and Caffeine Journal Article The purpose of the present study was to observe the psychosocial characteristics of withdrawal from cigarette smoking in comparison with those from caffeine (CAF) and alcoholic (ALC) beverage withdrawal.
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine Journal Article The ratio of nicotine metabolites (trans-3′-hydroxycotinine (3HC) to cotinine) correlates with nicotine clearance. In previous studies, high nicotine metabolite ratio (NMR) predicted poor outcomes for smoking cessation treatment with nicotine patch. The underlying mechanisms that associate NMR with treatment outcomes have not been fully elucidated.
Should criteria for drug dependence differ across drugs? Journal Article Aim To examine the pros and cons of using the same diagnostic criteria for dependence across all drugs versus using dependence criteria specific to the drug of interest.
The effects of cigarette smoking and abstinence on auditory verbal learning Journal Article Smoking has been associated with both enhanced and impaired cognitive performance; across a variety of domains, but there is limited evidence demonstrating the effects on verbal learning.
The effects of nicotine on human health | American Council on Science and Health (ACSH) Document Summary MORTALITY RISKS AND CANCER RISKS VARY GREATLY BY PRODUCT Cigarettes and smoking tobacco are the most deadly recreation products on shop shelves. Nicotine has been widely used as a medicine since 1984 and is safe at the doses used in medicines. Nicotine products do not cause lung or other cancers, nor lung or heart disease. Tobacco smoking, in contrast, is the main cause of lung cancer a…
The Fourth Pillar of the Framework Convention on Tobacco Control: Harm Reduction and the International Human Right to Health Journal Editorial Article Tobacco harm reduction as a human right Approximately one-quarter of all lifelong smokers will die in middle age (between 35 and 69) as a result of smoking and the authors of this 2006 paper (PDF) urge tobacco harm reduction to be viewed as a human right.
Treatment of nicotine addiction: present therapeutic options and pipeline developments Journal Article Tobacco use is a global pandemic that poses a substantial and costly health burden. There are some treatment options are available, but currently marketed smoking-cessation drugs lack high levels of efficacy, particularly in real-life settings. Consequently, there is a compelling need for more effective pharmacotherapies to aid smokers in maintaining long-term abstinence.
Use of a liquid nicotine delivery product to promote smoking cessation Journal Article Despite access to various pharmacotherapies and counseling support to aid cessation, smokers typically demonstrate quit rates below 50%. This report describes the results of a Phase 2a study exploring the efficacy of a liquid nicotine delivery system as an aid to smoking cessation assessed after 12 weeks of therapy. PMID: 20334673
Wake Up And Smell The Caffeine. It's A Powerful Drug Web Page Many of us can barely make it through the morning without first downing a cup of hot coffee. It's become such a big part of our daily rituals that few actually give much thought to what it is that we're putting in our bodies.
‘Real-world’ effectiveness of smoking cessation treatments: a population study Journal Article Background and aims There is a need for more evidence on the ‘real-world’ effectiveness of commonly used aids to smoking cessation from population-level studies.